Scientists uncover new function of a key protein – target of potent anti-cancer therapy

Dr. Radoslav Alexandrov and Assoc. Prof. Stoyno Stoynov PARP inhibitors are anticancer drugs that selectively inhibit the growth of tumors with deficiencies in DNA repair capacity, and are being approved for a growing number of indications. A deeper understanding of the mechanisms of action of PARP inhibitors as well as the function of their target PARP1 represent a hot topic in molecular oncology. Scientists from the Genomic Stability Laboratory and the Sofia Eurobioimaging Center for Advanced Light Microscopy at the Institute of Molecular Biology-BAS (IMB-BAS) are part of a thirteen-member interdisciplinary team that published a study on "PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends" in one of the three most prestigious journals in the world of [...]

2024-03-06T09:46:36+02:00Tuesday, 5 March 2024|Categories: Biomedicine and Quality of Life, Selected|
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ОOfficial closing of the National Scientific Programme ” Innovative low-toxic bioactive systems for precision medicine (BioActiveMed)”

On December 13, 2023, the official closure of the National Scientific Programme "Innovative Low-toxic Bioactive Agents for Precision Medicine (BioActiveMed)" was held in the “Prof. Marin Drinov” Hall of BAS. The presentation was attended by Corr. Memb. Evdokiya Pasheva - Vice-President of BAS, members of the leadership of BAS, members of AACM and representatives of higher education institutions. Mrs. Vesela Vassileva, State Expert at the Science Directorate, read a congratulatory address on behalf of Prof. Galin Tsokov - Minister of Education and Science. The programme is funded by the Ministry of Education and Science and is focused on conducting research to develop new low-toxic biologically active agents and systems containing extracts from natural sources (plant or animal origin) from Bulgaria for the prevention and support [...]

2023-12-18T10:26:59+02:00Thursday, 14 December 2023|Categories: Biomedicine and Quality of Life|
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BAS honoured the Institute of Experimental Morphology, Pathology and Anthropology with Museum with an honorary plaquette on the occasion of its 70th anniversary

  The Bulgarian Academy of Sciences honoured the Institute of Experimental Morphology, Pathology and Anthropology with a Museum (IEMPAM) with a GOLDEN honorary plaquette at a solemn ceremony held at the “Prof. Marin Drinov” Hall. The award is for outstanding contributions to scientific and applied research in the field of experimental morphology and pathology, anthropology and museum studies. On behalf of the leadership of the Academy, the Vice-President Corr. Memb. Evdokiya Pasheva presented the plaquette to the Director of the Institute Prof. Dr. Svetlozara Petkova. Your institute occupies one of the leading places in the field of biomedicine, emphasized in her address Corr. Memb. Pasheva. She wished more young people to be attracted by the institute in the coming years. The activities and successes of [...]

2023-12-01T11:54:25+02:00Tuesday, 28 November 2023|Categories: Biomedicine and Quality of Life, Selected|Tags: |
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BAS and Institut Curie discussed the construction of BioMedRTC

The Vice-President of the Bulgarian Academy of Sciences (BAS), Corr. Memb. Evdokiya Pasheva, and the Scientific Secretary of the "Biomedicine and Quality of Life" division, Corr. Memb. Nina Atanasova, met with Dorthe Nickel, member of the management of Institut Curie, Paris, an International Relations Officer. The meeting was held at BAS in connection with the establishment of BioMedRTC - Centre of Excellence in Biomedical Research and Technology. The Institut Curie is a world-renowned research institute founded in 1909 by Marie and Pierre Curie. The Institute is a leader in the fields of physics, chemistry, biology and medicine. The Curie Institute is a leading European centre for breast cancer treatment and one of the most prestigious in France devoted to research on the cellular mechanisms [...]

2023-10-25T11:22:35+03:00Monday, 23 October 2023|Categories: Biomedicine and Quality of Life, General news, Selected|
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Presentation of innovative bioactive agents for the needs of personalized and preventive medicine

Innovative biologically active agents for the needs of personalized and preventive medicine were presented at the Fourth Scientific Conference "Innovative Low-Toxic Biologically Active Agents for Precision Medicine", held from 12 to 16 June 2023. The scientific conference was held in the framework of the NRP BioActiveMed, with the leading organisation Bulgarian Academy of Sciences and the financial support of the Ministry of Education and Science. More than 50 scientists took part in the scientific forum and presented the results of the interdisciplinary research conducted in seven institutes of BAS and five universities. The presentations were divided into six scientific sessions and one poster session. Results were reported on the development of new biologically active systems containing extracts from natural sources of plant or animal origin [...]

2023-06-22T10:09:34+03:00Monday, 19 June 2023|Categories: Biomedicine and Quality of Life|
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Conference “Genome Structure and Function”

The ,,Roumen Tsanev'' Institute of Molecular Biology at BAS, Rice University (USA) and Institut Curie (France) are the organisers of the fifth international conference "Structure and Function of the Genome" https://genome2023.imb.bas.bg/ which takes place from June 5 to 8, 2023 in Sofia.  The conference is attended by more than 170 participants – both world-renowned scientists from the USA and Europe as well as many young researchers from around the world. The previous two scientific meetings in this series were held at the Massachusetts Institute of Technology (USA). In recent years, there has been a tremendous interest in understanding genome architecture and its role in the functioning of the organism in normal and pathological conditions. This has been made possible by the advent of technologies that [...]

2023-06-16T13:51:38+03:00Thursday, 8 June 2023|Categories: Biomedicine and Quality of Life|
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