Scientific achievements of IBIR in the field of single-cell transcriptomics
Scientists from the “Academician Kiril Bratanov” Institute of Biology and Immunology of Reproduction (IBIR-BAS) presented their latest findings in single-cell biology during the “Beyond Gene Expression: Single–Cell Isoform–Resolved Biology” international webinar organised jointly by the biotechnology companies ArgenTag and Oxford Nanopore Technologies. As a guest speaker, the institute’s director Corresponding Member Prof. Dr Soren Hayrabedyan, presented practical experience in the application of long-read sequencing of single cells. The data reveal previously unexplored mechanisms through which tumour cells transition to a more aggressive phenotype and evade the immune response. The results and bioinformatic analysis, developed by the team of Prof. Krassimira Todorova, DSc, show that over half of the key genes undergo a switch in their transcript forms (isoforms) without any change in the overall level [...]
